2 edition of role of ipratropium bromide in the management of acute asthma: a meta-analysis found in the catalog.
role of ipratropium bromide in the management of acute asthma: a meta-analysis
Written in English
Ottawa General Hospital
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The role of ipratropium bromide in the emergency management of acute asthma exacerbation: a meta-analysis of randomized clinical trials. -Sebaldt M, Kazim F, et al. Frequent administration of inhalation of salbutamol and ipratropium bromide in the initial management of severe acute asthma by: Many patients with asthma require frequent rescue medication for acute symptoms despite appropriate controller therapies. Thus, determining the most effective relief regimen is important in the management of more severe asthma. This study’s objective was to evaluate whether ipratropium bromide/albuterol metered-dose inhaler (CVT-MDI) provides more effective acute .
Peter J. Barnes, in Asthma and COPD (Second Edition), Acute severe asthma. Intravenous hydrocortisone is given in acute severe asthma, with a recommended dose of mg intravenously. While the value of corticosteroids in acute severe asthma has been questioned, others have found that they speed the resolution of attacks .There is no . The role of ipratropium bromide in the emergency management of acute asthma exacerbation: a metaanalysis of randomized clinical trials. Ann Emerg Med. Jul; [PubMed ID: ].
The symptoms include breathlessness and a chronic cough. Tiotropium is an inhaled medication, taken once a day, to help widen the airways (bronchodilator) and is used in the management of COPD. Ipratropium bromide is also a bronchodilator but has a shorter duration of action and has to be taken several times a day. Ipratropium bromide (atrovent) and atropine sulfate are achticholinergic drugs used for the treatment of asthma. Ipratropium is used for treating asthmatics in emergency situations with a nebulizer. Xopenex and ipratropium bromide do not appear to be commonly used together, but in a few cases have been.
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Stoodley R G, Aaron S D, Dales R E. The role of ipratropium bromide in the emergency management of acute asthma exacerbation; a metaanalysis of randomized clinical trials.
Annals of Emergency Medicine ; 34(1): [PubMed: ]Cited by: The role of anticholinergic bronchodilators, including ipratropium, however, in the management of acute exacerbations is less clear.
Stoodley and associates conducted a meta-analysis of all clinical trials in which ipratropium was used as an adjunct to beta 2 agonists in the treatment of acute asthma exacerbation in adults. The role of ipratropium bromide in the emergency management of acute asthma exacerbation: a metaanalysis of randomized clinical trials.
Stoodley RG(1), Aaron SD, Dales by: The role of ipratropium bromide in the emergency management of acute asthma exacerbation; a metaanalysis of randomized clinical trials: Stoodley R G, Aaron S D, Dales R E.
A meta-analysis examined the role of ipratropium bromide in the treatment of acute asthma in both adults and children.  There was a modest sta.
The purpose of this meta-analysis was to determine whether inhaled ipratropium bromide provides an additive benefit to adults with acute asthma who are treated with beta-agonists. A secondary goal was to determine whether the admission rate is influenced by the combined by: Although the clinical significance of this improvement in airflow obstruction remains unclear, it would seem reasonable to recommend the use of combination ipratropium/ β-agonist therapy in acute adult asthmatic exacerbations, since the addition of ipratropium seemed to provide physiologic evidence of benefit without risk of adverse effects.[Stoodley RG, Aaron SD, Dales RE: The role of ipratropium bromide in the emergency management of acute asthma Cited by: An overview of asthma management, the management of acute exacerbations of asthma at home and in the office, identification of risk factors for fatal asthma, and use of mechanical ventilation in severe exacerbations of asthma are discussed separately.
Ipratropium bromide, a short-acting muscarinic antagonist, was shown to decrease hospitalizations in children and adults with an asthma exacerbation. 11,12 Combination therapy of ipratropium and a short-acting β 2 agonist results in improvements in lung function compared with short-acting β 2 agonists alone, particularly during severe Cited by: 3.
The role for anticholinergic medications in acute asthma is not well-defined. Thus, the use of therapy with anticholinergics and β2-agonists, either simultaneously or in sequence, has produced positive as well as negative results in trials.
Therefore, the current recommendations for the use of these drugs in the emergency department (ED) and hospital management of asthma Cited by: Rodrigo G, Rodrigo C, Burschtin O. A meta-analysis of the effects of ipratropium bromide in adults with acute asthma. Am J Med. Oct; (4)– Stoodley RG, Aaron SD, Dales RE.
The role of ipratropium bromide in the emergency management of acute asthma exacerbation: a metaanalysis of randomized clinical by: () Ann Emerg 8.
Stoodley RG, Aaron SD, Dales RE. The role of ipratropium bromide in the emergency management of acute asthma exacerbation: a metaanalysis of randomized clinical trials. Jul. – [OpenUrl][CrossRef][PubMed][Web of Science] QUESTION: Is the addition of inhaled ipratropium bromide to β-agonist therapy effective in.
Stoodley RG, Aaron SD, Dales RE. The role of ipratropium bromide in the emergency management of acute asthma exacerbation: a meta-analysis of randomized clinical trials.
Ann Emerg Med ; 8 –Cited by: 5. Browne GJ, Trieu L, Van Asperen P. Randomized, double-blind, placebo-controlled trial of intravenous salbutamol and nebulized ipratropium bromide in early management of severe acute asthma in children presenting to an emergency department.
Crit Care Med. Feb;30(2) Rowe BH, Camargo CA : Tessa Davis. Rodriguez carried out a systematic review with meta-analysis to clarify the role of tiotropium in the treatment of patients with asthma of varying levels of severity .
They included 13 studies. Ipratropium bromide is a muscarinic cholinergic antagonist and is used in asthma, primarily in patients who either are intolerant of β2-agonists or are experiencing limited benefit from SABA use From: Middleton's Allergy Essentials, The literature on the role of ipratropium bromide in the treatment of childhood asthma in the emergency department setting is comprehensive, and includes a systematic review, 2 a meta-analysis, 19 and 2 recent, large, randomized, controlled trials.
12,13 These studies suggest that the addition of multiple doses (≤3 doses have been studied) of anticholinergic Cited by: Ipratropium bromide (Atrovent), a quaternary amine that does not cross the blood-brain barrier, is the recommended anticholenergic parasympatholytic agent of choice.
This synthetic ammonium compound is very similar structurally to atropine. Acute Bronchial Asthma. at 20 min interval) in all and ipratropium bromide and systemic steroids (hydrocortisone or methylprednisolone) in acute severe asthma.
Ipratropium may provide some additive benefit to inhaled beta-2 agonists when treating severe acute asthma exacerbations in the emergency department and, in some instances, during medical transport. There is a lack of evidence to support the use of ipratropium once a patient is hospitalized or as part of a chronic asthma regimen.
Some clinicians consider ipratropium as adjunctive therapy in patients with moderate or severe exacerbations (peak expiratory flow rate ≤80% of predicted) of asthma † who fail to respond adequately to β-adrenergic agonists and corticosteroids. May be useful for prevention or reversal of bronchospasm induced by β-adrenergic /In acute asthma the immediate PFR response to a mixture of salbutamol and ipratropium bromide was better than the response to nebulised salbutamol alone.
For COPD patients, the two treatments were.We designed a larger, double-blind, randomized, prospective trial to test our hypothesis that patients with acute asthma given combination high dose therapy with ipratropium bromide (IB) and β 2-agonists will have greater improvement in pulmonary function and fewer hospital admissions than those given β 2-agonists hundred eighty patients (mean age ± SD, Cited by: